AER

Improving Cardiac Resynchronisation Therapy

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CRT is an essential treatment for patients with heart failure and reduced ejection fraction as it can restore left ventricular (LV) electrical and mechanical synchrony. It has been shown to increase quality of life, improve functional status, reduce hospitalisation, improve LV systolic function and reduce mortality in properly selected patients.1,2 While CRT is an effective therapy, approximately 30% of patients treated with CRT do not benefit from it and some patients are negative responders.

Understanding AF Mechanisms Through Computational Modelling and Simulations

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The pathophysiology of AF is complex and incompletely understood to date.1,2 AF is a progressive disease of the atria involving a multitude of mechanisms related to its initiation, maintenance and progression.

Mapping and Imaging in Non-paroxysmal AF

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Maintenance of sinus rhythm in patients with non-paroxysmal AF is often challenging and complex. Catheter ablation is usually superior to anti-arrhythmic drug therapy alone. However, recurrence rates are high and have remained suboptimal. Although pulmonary vein isolation (PVI) is usually effective in treating paroxysmal AF, it is not sufficient for many patients with non-paroxysmal AF, particularly those with long-standing persistent AF. A major limitation is that our understanding of mechanisms of AF is incomplete.

The Role of Cardiac MRI in the Management of Ventricular Arrhythmias in Ischaemic and Non-ischaemic Dilated Cardiomyopathy

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This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

Ventricular tachycardia (VT) and VF occur mainly in people with impaired cardiac function and/or ischaemic heart disease, and account for the majority of sudden cardiac deaths worldwide.1 Treatment with anti-arrhythmic drugs such as amiodarone may be at best neutral in terms of mortality and carries significant long-term risks.2,3 While ICDs significantly improve survival for patients with significantly impaired left ventricular ejection fraction (LVEF), the devices also carry risk

Individualised Approaches for Catheter Ablation of AF: Patient Selection and Procedural Endpoints

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This work is open access under the CC-BY-NC 4.0 License which allows users to copy, redistribute and make derivative works for non-commercial purposes, provided the original work is cited correctly.

Catheter ablation (CA) is a widely used first-line treatment for AF.