BACKGROUND: Baseline data of the PREFER in AF (Prevention of thromboembolic events - European Registry in Atrial Fibrillation) Registry have shown undertreatment of patients with atrial fibrillation (AF), Particularly in Italy, where greater difficulties in the management of Antithrombotic drugs Compared with other European countries Also he was Observed. The aim of the follow-up evaluation was to verify the trends of variables Examined after 1 year.
METHODS: Clinical features, patterns of prescriptions and patient adherence to guidelines, quality-of-life and treatment satisfaction were Evaluated variables at follow-up, similarly to baseline.
RESULTS: In Italy, 88% of patients originally enrolled completed the 1-year follow-up. The incidence of major cardiovascular events was lower than at baseline (12.6 vs 30.8%, p <0.0001), but was higher Compared with the European mean (12.6 vs 10.4%, p = 0.0006). In Particular, the incidence of heart failure (5.1 vs. 3.6%, p = 0.0003) and transient ischemic attacks (1.4 vs 0.7%, p <0.0001) were more frequent in Italy; on the other hand, the incidence of major bleeding was lower in Italy Compared with the European mean (1.6 vs 2.4, p = 0.0168). Patients with a high thromboembolic risk (CHA 2 DS 2 -VASc ≥2) were> 80%, similarly to baseline, with a mean CHA 2 DS 2 -VASc score of 3.3. However, about one fourth of high-risk patients continued not to be treated with anticoagulant drugs, and treated patients at follow-up were fewer than at baseline (65.1 vs 72.6%, p <0.0001). The percentage of patients treated with non-vitamin K antagonist oral anticoagulants (NOACs) was Increased at follow-up Compared with baseline (3.3 vs. 0.3%, p <0.0001), Although lower than the European mean (12.6 vs. 6.1%, p < 0.0001). The number of INR measurements was related to higher and higher in time in therapeutic range (TTR), Compared with baseline, and exceeded the European mean TTR. However, similarly to baseline, a higher difficulty in managing anticoagulant therapy and a lower level of satisfaction for treatment was reported in Italian patients Compared with the rest of Europe.
CONCLUSIONS: The Italian date of the PREFER in AF registry at 1-year follow-up continued to demonstrate undertreatment of patients with AF at Increased risk of stroke and a high grade of unsatisfaction for anticoagulant treatment. The low percentage of patients treated with NOACs did not allow the evaluation of Their impact on clinical events and acceptance of therapy.