Stenting

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  • Coronary stenting improves blood supply to the heart muscle using stents to widen the coronary arteries.

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    Coronary stenting improves blood supply to the heart muscle using stents to widen the coronary arteries.

    Percutaneous coronary intervention is the most prevalent method for coronary artery revascularisation. With the introduction of coronary stents, vascular dissections were stabilised and arterial recoil was eliminated, but neointimal accumulation remained problematic, resulting in the development of in-stent restenosis (ISR) in 20–30% of cases. Drug-eluting stents (DESs) were developed to release antiproliferative agents at the site of arterial injury to attenuate neointimal formation. Although DESs have incrementally improved outcomes after percutaneous coronary intervention, delayed re-endothelialisation and stent thrombosis remain important challenges.

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