The prevalence of heart failure (HF) continues to increase over time1 and affects >60 million people each year2.
Therefore, being aware of the latest data in the HF space and different treatment options is important in order to be able to apply findings to clinical practice when making treatment decisions for patients with type 2 diabetes mellitus (T2DM) and cardiovascular disease, especially HF.
This review summarizes the latest developments in our understanding of the role of the innate and adaptive immune systems in the pathogenesis of heart failure and highlights the results of phase III clinical trials of therapies targeting...Adamo L, Rocha-Resende C, Prabhu SD, Mann DL. Nat Rev Cardiol 2020;17:269–85.
This article provides an approach for primary care physicians to managing peripheral oedema in people known to have heart failure in the community and the article includes a recap of the best available evidence.Bromage D, Mayhew J, Sado D. BMJ 2020;369:m2099.
Circulating plasma concentrations of angiotensin-converting enzyme 2 in men and women with heart failure and effects of renin–angiotensin–aldosterone inhibitors
The current pandemic coronavirus SARS-CoV-2 infects a wide age group but predominantly elderly individuals, especially men and those with cardiovascular disease. Recent reports suggest an association with use of renin–angiotensin–aldosterone...Sama IE, Ravera A, Santema BT, et al. Eur Heart J 2020;41:1810–7.
SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials
The authors carried out a systematic review and meta-analysis of randomised, placebo-controlled, cardiovascular outcome trials of SGLT2i in patients with type 2 diabetes.Zelniker TA, Wiviott SD, Raz I, et al. Lancet. 2019;393:31–9.
Marco Metra, Elisabetta Dinatolo, Nicolò Dasseni, et al
Andrew JS Coats, Giuseppe Rosano
Kazuma Hanajima, Yusuke Miyazaki, Yasufumi Katanasaka, et al
Moritake Iguchi, Shuichi Ura, Nobutoyo Masunaga, et al
Dai Ihara, Yusuke Watanabe, Daily Seya, et al
1.Heart disease and stroke statistics-2020 update: a report from the American Heart Association
Virani SS, Alonso A, Benjamin EJ, et al. Circulation 2020;141:e139-e596.
2. Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
GBD 2016 Disease and Injury Incidence and Prevalence Collaborators. Lancet 2017;390:1211-59.