Ventricular Fibrillation

Ventricular fibrillation (VF) is a common, life-threatening arrhythmia responsible for significant morbidity and mortality particularly in those with structural heart disease, inherited cardiomyopathies, and channelopathies.

Guideline-directed medical therapy and implantable cardioverter-defibrillator implantation remain the mainstay of therapy to prevent sudden cardiac death in patients with ventricular arrhythmias and structural heart disease. Recent advances in imaging modalities and commercial availability of genetic testing have enhanced the understanding of the disease processes and, along with significant progress in catheter-based ablative therapies, have enabled a tailored and more effective management of drug-refractory ventricular arrhythmias.