DDP-4 inhibitors versus sulphonylureas and cardiovascular outcomes: a meta-analysis of observational comparative studies


INTRODUCTION: Dipeptidyl peptidase IV inhibitors (DPP4i) and sulphonylureas are commonly prescribed antidiabetic treatments, particularly after the failure of metformin monotherapy. Although DPP4i have demonstrated non-inferiority versus to placebo in clinical trials, their relative effectiveness in reducing cardiovascular events compared to sulphonylureas was evaluated in observational studies.

AIMS: To evaluate the risk of mortality (all-cause and cardiovascular) and major cardiovascular adverse events (MACE) in patients treated with DPP4i versus sulphonylureas.

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Alves C, Mendes D, Batel Marques F. Presented at ATTD 2019.