Coronary Artery Spasm

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  • Coronary artery spasm (CAS) is an intense vasoconstriction of coronary arteries that causes total or subtotal vessel occlusion. It plays an important role in myocardial ischaemic syndromes, including stable and unstable angina, acute MI and sudden cardiac death. CAS differs from traditional stable angina pectoris – it is not directly related to effort or driven by atherosclerosis and lumen encroachment within the coronary vasculature.

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    Coronary artery spasm (CAS) is an intense vasoconstriction of coronary arteries that causes total or subtotal vessel occlusion. It plays an important role in myocardial ischaemic syndromes, including stable and unstable angina, acute MI and sudden cardiac death. CAS differs from traditional stable angina pectoris – it is not directly related to effort or driven by atherosclerosis and lumen encroachment within the coronary vasculature.

    Coronary angiography and provocative testing usually is required to establish a definitive diagnosis. There is no specific cure. Any factor that may precipitate CAS, especially smoking, must be avoided. For pharmaceutical treatment, calcium antagonists play a central role in the management of CAS and should be taken at night when attacks of CAS are frequent.

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