Perfusion CMR to guide patient management in stable angina

Perfusion CMR to guide patient management in stable angina

Prof Eike Nagel
Inst. for Experimental & Translational Cardiovascular Imaging 
DZHK Centre for Cardiovascular Imaging
University Hospital Frankfurt, DE

Myocardial perfusion imaging with cardiovascular magnetic resonance (CMR) has demonstrated excellent accuracy and prognostic value versus invasive angiography with or without fractional flow reserve (FFR). Direct comparisons to nuclear medicine have shown superior performance. Perfusion CMR can reduce the number of unnecessary invasive angiographies. Recent studies have shown that perfusion CMR can guide patients with stable angina with similar safety and outcomes, rather than the current standard of care, i.e invasive angiogrpahy plus fractional flow reserve. This webinar will lead you through the evidence, describe how to perform and interpret perfusion CMR and provide guidance on various clinical scenarios.

Professor Eike Nagel has been a frontrunner of CMR for the last three decades, validating, optimizing, standardizing and translating novel imaging opportunities into clinical practice. Most notably he has done major work in dobutamine stress MR and perfusion CMR. He is the Global Chief Investigator of the MR-INFORM trial, an international randomized controlled clinical effectiveness trial recently published in the New England Journal of Medicine1.


This webinar aims to educate and inform viewers on:

  • the latest the evidence on perfusion CMR.
  • understanding its advantages and limitations.
  • how to refer the right patient to a perfusion CMR study and understand the resulting report.
  • Cardiac imaging specialists
  • Physicians treating/investigating stable angina and chest pain
  • Radiologists

1. Nagel E, Greenwood JP, McCann GP, Bettencourt N, Shah AM, Hussain ST, Perera D, Plein S, Bucciarelli-Ducci C, Paul M, Westwood MA, Marber M, Richter WS, Puntmann VO, Schwenke C, Schulz-Menger J, Das R, Wong J, Hausenloy DJ, Steen H, Berry C; MR-INFORM Investigators. Magnetic Resonance Perfusion or Fractional Flow Reserve in Coronary Disease. N Engl J Med. 2019 Jun 20;380(25):2418-2428.

2. Greenwood JP, Ripley DP, Berry C, McCann GP, Plein S, Bucciarelli-Ducci C, Dall'Armellina E, Prasad A, Bijsterveld P, Foley JR, Mangion K, Sculpher M, Walker S, Everett CC, Cairns DA, Sharples LD, Brown JM; CE-MARC 2 Investigators. Effect of Care Guided by Cardiovascular Magnetic Resonance, Myocardial Perfusion Scintigraphy, or NICE Guidelines on Subsequent Unnecessary Angiography Rates: The CE-MARC 2 Randomized Clinical Trial. JAMA. 2016 Sep 13;316(10):1051-60.

3. Nagel E, Klein C, Paetsch I, Hettwer S, Schnackenburg B, Wegscheider K, Fleck E. Magnetic resonance perfusion measurements for the noninvasive detection of coronary artery disease. Circulation. 2003 Jul 29;108(4):432-7.

4. Greenwood JP, Maredia N, Younger JF, Brown JM, Nixon J, Everett CC, Bijsterveld P, Ridgway JP, Radjenovic A, Dickinson CJ, Ball SG, Plein S. Cardiovascular magnetic resonance and single-photon emission computed tomography for diagnosis of coronary heart disease (CE-MARC): a prospective trial. Lancet. 2012 Feb 4;379(9814):453-60. doi: 10.1016/S0140-6736(11)61335-4.

This is an independent Radcliffe production.