Assessment of Platelet REACtivity After Transcatheter Aortic Valve Implantation: REAC TAVI trial - Victor Jimenez Diaz.

Written by Katrina Mountford, Medical Editor.
19th March 2018

Abstract

Transcatheter aortic valve implantation (TAVI) has become the treatment of choice for patients with severe symptomatic aortic stenosis (AS). It is less invasive than surgical aortic valve replacement (SAVR), non-inferior to SAVR in terms of all-cause mortality at 2 years for patients at high and intermediate surgical risk. Its application in younger patients and those at lower surgical risk is now being explored. However, thrombotic and haemorrhagic complications following TAVI remain high and are a major cause of post-procedure mortality, necessitating antithrombotic therapy.2 In addition, the guideline recommendations for antithrombotic therapy for patients with AS undergoing TAVI are not standardised and not supported by randomised controlled trial data.1,3

The Assessment of Platelet reactivity after TAVI (REAC TAVI) trial was a prospective, multicentre, randomised open label parallel group study whose primary objective is to evaluate the effectiveness of ticagrelor compared with clopidogrel for the suppression of residual platelet reactivity after TAVI. Its efficacy endpoint was the suppression of residual platelet reactivity in ≤70 % of patients treated with ticagrelor. Inclusion criteria were degenerative severe AS accepted for TAVI by transfemoral, subclavian or axillary access. The main exclusion criteria were use of chronic oral anticoagulants (OAC) or patients for whom dual (DAPT) or single antiplatelet therapy (SAPT) for 3 months was contraindicated due to a new post-TAVI medical indication. Of 65 patients undergoing TAVI under clopidogrel and aspirin, all were assessed with the VerifyNow system aspirin and P2Y12 assays before TAVI. 19 patients (29 %) had normal platelet reactivity (P2Y12 Reaction Units [PRU] <208) and did not undergo treatment modification. The remaining 46 patients were randomised to standard treatment with DAPT (clopidogrel 75 mg + aspirin 100 mg, 24 patients) or ticagrelor (90 mg twice daily + aspirinA initiated 24 hours before TAVI, 22 patients).

After 3 months of treatment following TAVI, the PRU was 64 in the ticagrelor group, 163 in the registry group and 242 in the clopidogrel group, with the primary endpoint achieved in 100 % of the ticagrelor group and 21 % in the clopidogrel group. In-hospital major bleeding complications occurred in 25 % of the clopidogrel group compared with 4 % in the ticagrelor group. In-hospital mortality was 8 % in the clopidogrel group and none in the ticagrelor group. However, these differences were not significant.

Mean PRU values along 3 months of treatment following TAVI

In summary, clopidogrel does not achieve adequate platelet inhibition before and after TAVI in most patients. By contract, ticagrelor is effective for the suppression of high platelet reactivity after TAVI with its effect maintained over 3 months following TAVI. This study was limited by its small sample size and short follow-up, but has demonstrated that a large randomised trial powered for clinical endpoints is needed.

References

  1. Nishimura RA, Otto CM, Bonow RO, et al., 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, J Am Coll Cardiol, 2017;70:252-89.X
  2. Gargiulo G, Valgimigli M, Antithrombotic therapy after transcatheter aortic valve implantation: a new piece of the still unresolved puzzle, J Thorac Dis, 2017;9:4260-5.
  3. Falk V, Baumgartner H, Bax JJ, et al., 2017 ESC/EACTS Guidelines for the management of valvular heart disease, Eur J Cardiothorac Surg, 2017;52:616-64.