This is the third set of Guidelines produced by the ESC in collaboration with the EASD, designed to provide guidance on the management and prevention of cardiovascular (CV) disease (CVD) in subjects with, and at risk of developing, diabetes mellitus (DM). The last Guidelines on this subject were published in the European Heart Journal in 2013. The interval between preparing the previous Guidelines and the current document has been relatively short, but it has been a period in which we have seen an unprecedented increase in the evidence base available for practicing healthcare professionals to refer to in their daily consultations. This has been characterized by the presentation and publication of a number of CV safety trials for type 2 DM (T2DM) treatments, the results of which, to the casual observer, must seem both exciting and bewildering. Exciting, because while all the recent studies have reported CV safety, several have also reported, for the first time, clear evidence of CV benefit. Bewildering, because these trials continue to be dogged by various side effects that dull the clarity of decision-making. It is one of our aims to guide the reader through this important data set.
European Heart Journal, ehz486