Despite the fast advances experienced over the last few years, Proteomics is still at its youthfulness. It is a discipline with a tremendous future that offers all kinds of opportunities to analyze biological systems with unprecedented efficacy to generate new concepts in biology, identify new diagnostic and therapeutic targets and study drug effects in cell biology. The challenge of defining and understanding proteomes in the context of cell biology is huge and requires a multidisciplinary effort to ensure innovative technical developments, the generation of biological information as well as the integration and interpretation tools to transform the information into biological knowledge. We sincerely hope to have been able to create an ideal environment where international experts can discuss all these aspects generating new ideas and establishing productive scientific interactions.