Speckle Tracking Echocardiography

European Cardiology Review, 2007;3(1):1-3

Speckle tracking echocardiography (STE) is a new, non-invasive method for the assessment of left ventricular (LV) global and regional function. STE offers the opportunity to track myocardial deformation independently of both cardiac translation and the insonation angle. Before the advent of STE, the only technique for angle-independent assessment of LV deformation and rotation was tagged cardiac magnetic resonance (cMR). Although tagged cMR remains the reference method for the assessment of LV deformation, its use is limited by an inherent low frame rate acquisition, high cost, and time-consuming and complex data analysis. Recently, STE was proposed as an alternative method to assess LV deformation and torsion, and it has been systematically validated by reference to sonomicrometry, tagged cMR and colour-coded tissue Doppler echocardiography. Several studies have proven its accuracy and consistency.

Because of scattering, reflection and interference of the ultrasound beam in myocardial tissue, speckles appear in grey scale two-dimensional (2-D) echographic images. These speckles represent tissue markers that can be tracked from frame to frame throughout the cardiac cycle (see Figure1).

These fingerprints are randomly distributed throughout the myocardium. Each speckle can be identified and tracked by calculating frame to frame changes – similar to analysis with tagged cMR – using a sum of absolute difference algorithms. Motion is analysed by integrating frame to frame changes. Out-of-plane motion occurs due to rotation and motion of the heart into the chest cavity, and may cause the disappearance of the speckles over a few frames, but rarely within two consecutive frames. Philips Tissue Motion Quantification (TMQ) software allows spatial and temporal processing of these markers on 2-D ultrasound images. TMQ speckle tracking also offers an alternative to techniques such as colour-coded tissue Doppler for strain, and strain rate imaging, overcoming many of the problems traditionally associated with angle dependence. A significant advantage consists in the possibility of interrogating radial, circumferential and longitudinal deformation simultaneously from the same acquired loop. By tracking these speckles, the strain, strain rate, tissue velocity and LV rotation can be easily calculated.

References:
  1. Kukulski T, Jamal F, D’Hooge J, et al. Acute changes in systolic and diastolic events during clinical coronary angioplasty: a comparison of regional velocity, strain rate, and strain measurement, J Am Soc Echocardiogr, 2002;15:1–12.
  2. Marwick TH; Measurement of strain and strain rate by echocardiography: ready for prime time? J Am Coll Cardiol, 2006;47:1313–27.
  3. Hashimoto I, Li X, Hejmadi Bhat A, et al. Myocardial strain rate is a superior method for evaluation of left ventricular subendocardial function compared with tissue Doppler imaging, J Am Coll Cardiol, 2003;42:1574–83.
  4. Pislaru C, Abraham TP, Belohlavek M. Strain and strain rate echocardiography, Curr Opin Cardiol, 2002;17:443–54.
  5. Stoylen A, Heimdal A, Bjornstad K, et al. Strain rate imaging by ultrasonography in the diagnosis of coronary artery disease, J Am Soc Echocardiogr, 2000;13:1053–64.
  6. Voigt JU, Arnold MF, Karlsson M, et al. Assessment of regional longitudinal myocardial strain rate derived from Doppler myocardial imaging indexes in normal and infarcted myocardium, J Am Soc Echocardiogr, 2000;13:588–98.
  7. Voigt JU, Flachskampf FA; Strain and strain rate. New and clinically relevant echo parameters of regional myocardial function. Z Kardiol, 2004;93:249–58.
  8. Yip G, Abraham T, Belohlavek M, et al. Clinical applications of strain rate imaging. J Am Soc Echocardiogr, 2003;16:1334–42.
  9. Amundsen BH, Helle-Valle T, Edvardsen T et al. Noninvasive myocardial strain measurement by speckle tracking echocardiography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol, 2006;47:789–93.
  10. Helle-Valle T, Crosby J, Edvardsen T, et al. New noninvasive method for assessment of left ventricular rotation: speckle tracking echocardiography.Circulation, 2005;112:3149–56.
  11. Notomi Y, Lysyansky P, Setser RM, et al. Measurement of ventricular torsion by two-dimensional ultrasound speckle tracking imaging, J Am Coll Cardiol, 2005;45:2034–41.
  12. Suffoletto MS, Dohi K, Cannesson M, et al. Novel speckletracking radial strain from routine black-and-white echocardiographic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy. Circulation, 2006;113:960–8.

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