Platelet Function Testing in High-risk Coronary Artery Disease Patients - An Update

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Abstract

Following activation and aggregation, human platelets play an important role in promoting vascular and stent thrombosis. By inhibiting platelets, aspirin and clopidogrel limit this process; used in combination they are particularly helpful when administered to patients with acute coronary syndromes undergoing percutaneous coronary intervention with stenting. Platelet function is traditionally assessed by light transmission aggregation (LTA) test in platelet-rich plasma (PRP). By using different agonists to induce aggregation, the extent of platelet inhibition can be monitored. As platelet LTA presents some drawbacks (manual sample preparation, selection of agonists and their concentration, time-consuming), new and renewed automated systems have been introduced to provide a simple, rapid assessment of platelet function, including point-of-care (POC) methods that are also suitable for use in non-specialized laboratories.

Disclosure
The author has no conflicts of interest to declare.
Correspondence
Rita Paniccia, PhD, Thrombosis Center, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni, 85 50134 Florence, Italy. E: rita.paniccia@unifi.it
Received date
06 November 2008
Accepted date
09 January 2009
Citation
US Cardiology - Volume 6 Issue 1;2009:6(1):75-80
Correspondence
Rita Paniccia, PhD, Thrombosis Center, University of Florence, Azienda Ospedaliero-Universitaria Careggi, Viale Morgagni, 85 50134 Florence, Italy. E: rita.paniccia@unifi.it
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